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The University of Electro-Communications  Graduate School of Informatics and Engineering, School of Informatics and Engineering  Department of Engineering Science, Cluster III （Fundamental Science and Engineering）

Associate Professor  GEN-ICHI SAMPEI  Year of birth:1960   Tel.0424-43-5481   Fax.0424-43-5501     Personal website

■ Career 東京大学理学部  助手  1989/06/16-1993/03/31  東京大学大学院理学系研究科  助手  1993/04/01-1994/03/31  電気通信大学電気通信学部  助手  1994/04/01-1999/11/24  電気通信大学電気通信学部  講師  1999/11/25-2010/03/31  電気通信大学大学院情報理工学研究科  講師  2010/04/01-2014/03/31  電気通信大学大学院情報理工学研究科  准教授  2014/04/01-Present    ■ Academic background 福島県立安積高等学校  普通科  1979/03/31  Graduated  The University of Tokyo  Faculty of Science  生物化学科  1984/03/31  Graduated  The University of Tokyo  Graduate School, Division of Science  生物化学専攻  Master's program  1986/03/31  Completed  The University of Tokyo  Graduate School, Division of Science  生物化学専攻  Doctoral program  1989/06/15  Program completed without degree  The University of Tokyo  Graduate School, Division of Science  生物化学専攻  Doctoral program  1990/03/31  Completed    ■ Academic degrees 理学博士  The University of Tokyo  1990/03    ■ Classes responsible within the university 2018  Bioscience and Technology Laboratory Ⅰ  Spring semester  Undergraduate, daytime  Subject in specialty  2018  General Biochemistry  Spring semester  Undergraduate, daytime  Subject in specialty  2018  Instrumental Analysis  Spring semester  Undergraduate, daytime  Subject in specialty  2018  Molecular Biology  Fall semester  Undergraduate, daytime  Subject in specialty  2018  Bioscience and Technology Laboratory ⅠI  Fall semester  Undergraduate, daytime  Subject in specialty  View details...   ■ Current research areas Molecular biology  Genome biology  Structural biochemistry    ■ Research keywords Genome  Organization  Diversification  Biosynthetic pathway  X-ray crystallography  Regulation of gene expression  System's biology  Metabolic system    ■ Current research subjects X-ray crystallographic analysis of the purine nucleotide biosynthetic enzymes from various thermophilic bacteria with focusing on Thermus thermophilus.  X-ray crystallography purine nucleotide biosynthetic pathway thermophilic bacteria  2002-Present  Regulation of gene expression in the purine nucleotide biosynthetic operons from Thermus thermophilus  gene expression purine biosythetic pathway  2002-Present  Organization of purinc nucleotidc biosynthetic pathway  Organization purine nucleotide  1997-Present  Organization and diversification of plasmid genomes  plasmid genome  1996-2012    ■ Published books Book  基礎生化学実験  三瓶嚴一（分担執筆）  東京化学同人  107-129  1994/11  Book  構造生物学 -ポストゲノム時代のタンパク質研究-  三瓶嚴一（分担執筆）  共立出版  227-234  2007/04  View details...   ■ Published papers Paper  Yes  RNomics of Thermus thermophilus HB8 by DNA microarray and next-generation sequencing  Joint  Gota Kawai, Yuri Aoki, Maina Otsu, Naomi Koike, Gen-ichi Sampei  J Biochem.  162/ 6, 423-430  2017/11  Paper  Yes  Crystal structures of a subunit of the formylglycinamide ribonucleotide amidotransferase, PurS, from Thermus thermophilus, Sulfolobus tokodaii and Methanocaldococcus jannaschii  Joint  Yuzo Watanabe, Hisaaki Yanai, Mayumi Kanagawa, Sakiko Suzuki, Satoko Tamura, Kiyoshi Okada, Seiki Baba, Takashi Kumasaka, Yoshihiro Agari, Lirong Chen, Zheng-Qing Fu, John Chrzas, Bi-Cheng Wang, NorikoNakagawa, Akio Ebihara, Ryoji Masui, Seiki Kuramitsu, Shigeyuki Yokoyama, Gen-ichi Sampei and Gota Kawai  Acta Crystallogr Sect F Struct Biol Cryst Commun.  72, 627-635  2016/08/01  Paper  Yes  Structures and reaction mechanisms of the two related enzymes, PurN and PurU.  Joint  Gen-ichi Sampei, Mayumi Kanagawa, Seiki Baba, Toshiaki Shimasaki, Hiroyuki Taka, Shohei Mitsui, Shinji Fujiwara, Yuki Yanagida, Mayumi Kusano, Sakiko Suzuki, Kayoko Terao, Hiroya Kawai, Yoko Fukai, Noriko Nakagawa, Akio Ebihara, Seiki Kuramitsu, Shigeyuki Yokoyama　and Gota Kawai  J Biochem.  154/ 6, 569-579  2013/12  Paper  Yes  Structure of N-formylglycinamide ribonucleotide amidotransferase II (PurL) from Thermus thermophilus HB8  Joint  Sakiko Suzuki, Hisaaki Yanai, Mayumi Kanagawa, Satoko Tamura, Yuzo Watanabe, Kyotaro Fuse, Seiki Baba, Gen-ichi Sampei and Gota Kawai  Acta Crystallogr Sect F Struct Biol Cryst Commun.  68, 14-19  2012/01  Paper  Yes  Crystal Structures of Glycinamide Ribonucleotide Synthetase, PurD, from Thermophilic Eubacteria.  Joint  Gen-ichi Sampei., Seiki Baba, Mayumi Kanagawa, Hsaaki Yanai, Takeshi Ishii, Hiroya Kawai, Yoko Fukai, Akio Ebihara , NorikoNakagawa, Gota Kawai  J Biochem.  148/ 4, 429-438  2010/10  View details...   ■ Research presentations Oral presentation for an academic conference  好熱性メタン菌由来purPとpurOによる大腸菌purH遺伝子の相補  生命科学系学会合同年次大会，第40回日本分子生物学会年会，第90回日本生化学会大会  No  天貝 雄歩，三瓶 嚴一，河合 剛太，根本 直樹  2017/12/08  Oral presentation for an academic conference  DNAマイクロアレイと次世代シーケンサーによるThermus themophilus HB8のRNomics  生命科学系学会合同年次大会，第40回日本分子生物学会年会，第90回日本生化学会大会  No  河合 剛太，青木 優里，大津 舞菜，小池 奈緒美，三瓶 嚴一  2017/12/06  Oral presentation for an academic conference  Sulfolobus tokodaii 由来PurQタンパク質の無細胞合成系による調製とグルタミナーゼ活性の確認  第87回日本生化学会大会  No  渡辺雄三, 三瓶嚴一, 河合剛太  2014/10  Oral presentation for an academic conference  Crystal structures of PurM proteins from thermophiles  第87回日本生化学会大会  No  Mayumi Kanazawa, Seiki Baba, Yuzo Watanabe, Gen-ichi Sampei, Gota Kawai  2014/10  Oral presentation for an academic conference  Origin and evolution of the protein structures in the purine biosynthetic pathway : Reaction mechanism of N5-CAIR synthetase (PurK) and evolutionary relationships with related enzymes  第87回日本生化学会大会  No  Gen-ichi Sampei and Gota Kawai  2014/10  View details...   ■ Intellectual property rights Patent  新規プラスミド及び当該プラスミドを含むシャトルベクター  特願2002-309721  2002/10/24  特開2004-141065  2004/05/20  Published  View details...   ■ Researcher accepted Domestic  Post-doctoral researcher  日本  プリン・プリミジンヌクレオチド生合成系酵素の立体構造解析  2006-2007  View details...   ■ Past records of joint or funded research 乳酸菌ゲノムの解析  2001-2002  Commissioned research  Research commissioned by a company  View details...   ■ Memberships of academic societies 日本分子生物学会  1984-Present  日本生化学会  2013/01/17-Present  日本結晶学会  2001-Present  モデル生物丸ごと一匹学会  2011/08-Present  View details...   ■ Involvement in conference and research meetings 電気通信大学生命科学シンポジウム 『生命システム原材料の起源と進化：生化学的禁制律』  オーガナイザー  2013/03/09  理研・千葉工業大学共催シンポジウム「生命システム原材料の起源と進化：生体分子は如何にして作られたか？」  企画・運営委員  2011/11/26  View details...   ■ Committee or council involvement モデル生物丸ごと一匹学会  理事  2011/08-Present  View details...   ■ Social activities Participation in community support activities, etc.  杉並区立宮前公園竹林の集い  2016/04/23-Present  公園内に自生している竹林の保全のために間伐を行う。および，地域の子供たちに竹の加工の仕方を指導する。  View details...   ■ Committee activity in the University 広報委員会  委員  2017/04-Present  情報基盤システム仕様策定委員会  委員  2017/01-2017/06  学部教育委員会  委員  2015/02-2017/03  教職課程部会  委員  2013/04-2015/03  安全・環境保全室薬品管理部門  部門員  2011/02-Present  View details...